C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2438386
The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne de nouveaux polynucléotides codant les polypeptides HGRA4, des fragments et des homologues de ces derniers. L'invention a également trait à des nouveaux polynucléotides codant un variant d'épissage de HGRA4, le HGRA4sv. L'invention porte aussi sur des vecteurs, des cellules hôtes, des anticorps, et sur des méthodes de recombinaison et de synthèse permettant de fabriquer lesdits polypeptides. L'invention se rapporte aussi à des méthodes diagnostiques et thérapeutiques permettant d'utiliser ces nouveaux polypeptides HGRA4 et HGRA4vs afin de diagnostiquer, de traiter et/ou de prévenir différent(e)s maladies et/ou troubles liés à ces polypeptides. L'invention a également pour objet des méthodes de criblage servant à identifier des agonistes et des antagonistes des polynucléotides et des polypeptides susmentionnés.
Chang Han
Chen Jian
Feder John
Jackson Donald G.
Lee Liana
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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