C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2443909
The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne de nouveaux polynucléotides codant les polypeptides HGPRBMY28 et HGPRBMY29, des fragments et des homologues de ceux-ci. L'invention concerne également des polynucléotides codant des variants d'épissage de polypeptides HGPRBMY29, HGPRBMY29v1 et HGPRBMY29v2. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps, ainsi que des méthodes de recombinaison et de synthèse permettant de produire lesdits polypeptides. L'invention concerne encore des méthodes thérapeutiques et diagnostiques permettant d'appliquer les nouveaux polypeptides HGPRBMY28, HGPRBMY29, HGPRBMY29v1 et HGPRBMY29v2 au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou troubles liés à ces polypeptides. L'invention concerne enfin des méthodes de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides selon l'invention.
Bol David
Feder John
Hawken Donald R.
Mintier Gabriel
Ramanathan Chandra
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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