C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2403912
The present invention relates to polynucleotides that control desaturase genes and to drug screening assays for identifying pharmaceutially active compounds for use in the treatment of diseases involving abnormal lipid metabolism including diabetic neuropathy, by utilizing fatty acid desaturase enzymes and the genes which encode them as targets for intervention. The drug screening method identifies nucleotides, proteins, compounds and/or other pharmacological agents, which effectively modulate the activity of desaturase enzymes or regulate the level of expression of the desaturase genes.
Cette invention a trait à des polynucléotides agissant sur des gènes de désaturase ainsi qu'à des épreuves de criblage de médicaments permettant d'identifier des composés actifs du point de vue pharmaceutique à utiliser pour traiter des états pathologiques se traduisant par un métabolisme anormal des lipides, notamment la neuropathie diabétique, avec utilisation de désaturase d'acides gras et les gènes qui la codent comme cibles pour intervention. L'épreuve de criblage de médicament permet d'identifier des nucléotides, des protéines, des composés et/au d'autres agents pharmacologiques, modulant efficacement l'activité des désaturases ou régulant le taux d'expression des gènes de désaturase.
Allen Stephen John
de Antueno Roberto Justo
Ponton Andre
Smith Heidi Lynn
Winther Michael David
Ridout & Maybee Llp
Scotia Holdings Plc
Xenon Genetics Inc.
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