Polypeptide

Details Polypeptide Polypeptide

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/275 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 15/863 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2351622

The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.

Cette invention a trait à un antigène associé à une tumeur (TAA) 5T4 utilisé dans une méthode immunothérapique de traitement de tumeurs. Elle concerne également un vecteur poxviral de recombinaison dont au moins un gène d'évasion immune a été détruit, comprenant une séquence nucléotidique codant un TAA 5T4, ainsi que son utilisation en matière de vaccination antitumorale et de traitement de tumeurs.

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