Polypeptide and dnas encoding it

Details Polypeptide and dnas encoding it Polypeptide and dnas encoding it

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2120476

A B S T R A C T The present invention is related to novel polypeptide consisting of 327 amino acids which is produced in a human glioblastoma cell line, a method of producing it, DNA encoding the said polypeptide, a fragment capable of selectively hybridizing to the DNA sequence, a replication or expression vector comprising the DNA and a host cell tranformed with the replication or expression vector. The polypeptide of the present invention may be useful for the prevention of or in the treatment of aplasia or abnormal proliferation, of glias or neurons, depression or enhancement of activity, or tumors, diabetes mellitus, diseases caused by abnormal glycometabolism or in the treatment diseases related to transaldorase. 28

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