Polypeptide antigen inducing hiv neutralizing antibodies

Details Polypeptide antigen inducing hiv neutralizing antibodies Polypeptide antigen inducing hiv neutralizing antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 15/85 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2485453

The invention concerns a polypeptide of formula N-L-C, wherein N represents the sequence of amino acids 25-81 of gp41, C represents the sequence of amino acids 112-157 of gp41, and L represents the flexible linker comprising 2 to 30 amino acids, for preparing a pharmaceutical composition for inducing antibodies neutralizing HIV primary isolates.

La présente invention a pour objet un polypeptide représenté par la formule :N-L-C-, dans la quelle : N représente la séquence des acides aminés 25-81 de la gp41, C représente la séquence des acides aminés 112-157 de la gp41, et L représente une séquence de liaison flexible comprenant de 2 à 30 acides aminés, pour la préparation d~une composition pharmaceutique pour l~induction d~anticorps neutralisant les isolats primaires du HIV.

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