Polypeptide cleavage process

A - Human Necessities – 61 – K

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Details

IPC codes

A61K 33/24 (2006.01) A01N 59/16 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) C07K 1/12 (2006.01) C07K 14/60 (2006.01) C07K 14/635 (2006.01)

Type

Patent

Patent number

CA 2485959

Description

The invention provides a palladium-promoted hydrolytic polypeptide cleavage process which selectively cleaves the polypeptide at a Cys-His cleavage site comprising solubilizing the polypeptide in a reaction mixture comprised of a palladium promotor dissolved in a high- concentration formic acid, wherein the concentration of the formic acid in the reaction mixture is between about 1 to about 22 molar.

L'invention concerne un procédé de clivage par hydrolyse d'un polypeptide, qui produit un clivage sélectif du polypeptide au niveau d'un site de clivage Cys-His. Ce procédé consiste à solubiliser le polypeptide dans un mélange réactionnel composé d'un promoteur palladium dissous dans de l'acide formique hautement concentré, la concentration d'acide formique dans le mélange réactionnel étant approximativement comprise entre 1 et 22 molaire.

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