C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/1.06, 530/7.
C07K 7/06 (2006.01) C07K 1/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1328948
A B S T R A C T The invention relates to a polypeptide of formula I:- R1-CO-A1-A2-A3-A4-A5-A6-Q I wherein each of the generic terms is disclosed in full in the specification and includes:- R1 is a 5- or 6-membered unsaturated heterocyclic ring which contains one, two or three nitrogen atoms, which ring may optionally bear one or two substituents A1 is a direct link to A2, or is His or D-His; A2 is Trp or MeTrp; A3 is Ala or MeAla; A4 is Val; A5 is Gly or D-Ala; A6 is His or Lys(Z); and Q is a group of the formula -A7.R2 in which A7 is Leu or MeLeu and R2 is hydroxy, amino, (1-3C)alkylamino or (1- 3C)alkoxy; or Q is (1-6C)alkoxy or (1-10C)alkylamino. The compounds possess antagonist properties against bombesin-like peptides and are of value in the treatment of malignant disease in warm-blooded animals.
601751
Cotton Ronald
Dutta Anand Swaroop
Imperial Chemical Industries Plc
Smart & Biggar
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