Polypeptide comprising a knottin protein moiety

Details Polypeptide comprising a knottin protein moiety Polypeptide comprising a knottin protein moiety

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2678468

The present invention is related to a polypeptide comprising a scaffold moiety and a helix moiety, whereby the helix moiety is inserted into the scaffold moiety, the scaffold moiety comprises a knottin protein or at least one fragment thereof, and the amino acid sequence of the polypeptide differs from the amino acid sequence of the knottin protein or at least one fragment thereof.

L'invention concerne un polypeptide qui comprend un fragment squelette et un fragment hélice, le fragment hélice étant inséré dans le fragment squelette, le fragment squelette comprenant une protéine knottine ou au moins un fragment de cette dernière, et la séquence d'acides aminés du polypeptide étant différente de la séquence d'acides aminés de la protéine knottine ou d'au moins un fragment de cette dernière.

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