C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/00 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2055425
ABSTRACT OF THE INVENTION This invention provides a novel polypeptide which comprises an amino acid sequence that constitutes a portion of urinary trypsin inhibitor (UTI) and which has no antigenicity against human and high activity to inhibit various proteases, as well as other novel polypeptides having excellent activities to inhibit various proteases obtained by mutation of the former novel polypeptide. This invention also provides novel enzyme inhibition processes, drug compositions and treating methods making use of the novel polypeptide, DNA fragments containing nucleotide sequences which encode the novel polypeptides, vectors containing the DNA fragments and transformants transformed with the DNA fragments or the vectors, as well as processes for the production of the novel polypeptides.
Kanamori Toshinori
Morishita Hideaki
Nobuhara Masahiro
Mochida Pharmaceutical Co. Ltd.
Smart & Biggar
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