Polypeptide, dna fragment encoding the same, drug...

Details Polypeptide, dna fragment encoding the same, drug... Polypeptide, dna fragment encoding the same, drug...

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/02 (2006.01) A61K 38/57 (2006.01) C07K 2/00 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082226

ABSTRACT OF THE INVENTION This invention particularly provides a novel polypeptide having high protease-inhibiting activity, preferably FXa- inhibiting activity, which comprises, at least as a part of the polypeptide, an amino acid sequence resulting from substitution of an amino acid for at least one amino acid in the following amino acid sequence (1), wherein the amino acid substitution is at least one substitution selected from the following substitution means (i) to (iii). It also provides a process for the production of the polypeptide, a novel DNA fragment encoding the polypeptide and a drug composition containing the same. Amino acid sequence (1) Image (i) Substitution of 15 position Gln counting from the N- terminus by an amino acid other than Gln. (ii) Substitution of 42 position Tyr counting from the N- terminus by an amino acid other than Tyr. (iii) Substitution of 7 position Arg counting from the N- terminus by an amino acid other than Arg.

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