Polypeptide for unstabilizing a protein in a cell under...

Details Polypeptide for unstabilizing a protein in a cell under... Polypeptide for unstabilizing a protein in a cell under...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2449802

To identify a domain participating in the stabilization of HIF-1.alpha. protein, DNA encoding the following polypeptide (A) or (B) is provided. (A) A polypeptide comprising the amino acid sequence represented by SEQ ID NO:1. (B) A polypeptide comprising an amino acid sequence consisting of at least 16 amino acid residues in the amino acid sequence represented by SEQ ID NO:1 and, when fused with a nuclear localization signal and another protein, imparting a stability depending on oxygen concentration to the other protein in cells carrying the fused protein.

L'invention concerne un ADN codant pour les polypeptides (A) ou (B), permettant d'identifier un domaine participant à la stabilisation de la protéine HIF-1 alpha. Le polypeptide (A) comprend la séquence d'acides aminés représentée par la séquence SEQ ID NO:1. Le polypeptide (B) comprend une séquence d'acides aminés comprenant au moins 16 résidus d'acides aminés dans la séquence d'acides aminés représentée par la séquence SEQ ID NO:1. Lorsqu'il est fusionné avec un signal de localisation nucléaire et une autre protéine, cet ADN confère une stabilité dépendant de la concentration d'oxygène à l'autre protéine dans des cellules transportant la protéine fusionnée.

Affiliated with

Also associated with

Rating

Polypeptide for unstabilizing a protein in a cell under... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptide for unstabilizing a protein in a cell under..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptide for unstabilizing a protein in a cell under... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1647134