C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/08 (2006.01) A61K 38/44 (2006.01) A61P 1/04 (2006.01) A61P 31/04 (2006.01) A61P 43/00 (2006.01) C07K 14/205 (2006.01) C07K 14/47 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2387392
An isolated polypeptide and immunogenic fragments thereof are described together with their variants and derivatives as novel immunogenic agents for treating or preventing Helicobacter infection in a mammalian host. The polypeptide comprises a C-terminal portion of a Helicobacter catalase, which portion lacks significant amino acid sequence identity with human catalase, wherein the polypeptide is other than full-length Helicobacter catalase.
L'invention se rapporte à un polypeptide isolé et à des fragments immunogènes de ce polypeptide, ainsi qu'à leurs variants et dérivés utilisés en tant qu'agents immunogènes pour le traitement ou la prévention des infections par Helicobacter chez un hôte mammalien. Ce polypeptide comporte une partie C-terminale d'une Helicobacter catalase, qui est une partie ne présentant pas d'identité significative de séquence d'acides aminés avec la catalase humaine. Ce polypeptide est autre qu'une Helicobacter catalase pleine longueur.
Doidge Christopher Vincent
Hazell Stuart Lloyd
Rothel Linda Joy
Sutton Philip
Webb Elizabeth Ann
Csl Limited
Sim & Mcburney
The University Of New South Wales
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