Polypeptide having an activity to support proliferation or...

Details Polypeptide having an activity to support proliferation or... Polypeptide having an activity to support proliferation or...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C12N 5/0789 (2010.01) A61K 38/18 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2449259

A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.

L'invention concerne un gène qui code un polypeptide à activité entretenant la prolifération ou la survie des cellules souches hématopoïétiques ou des progéniteurs hématopoïétiques, isolé par comparaison de gènes exprimés entre des cellules qui ont l'activité d'entretien susmentionnée, d'une part, et des cellules qui n'ont pas cette activité, d'autre part. On entretient ladite activité en utilisant des cellules de stroma dans lesquelles est exprimé le gène isolé ou un produit génique de ce gène.

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