C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/63 (2006.01) C12P 7/18 (2006.01) C12P 7/28 (2006.01) C12P 7/56 (2006.01)
Patent
CA 2715737
The present invention relates to a novel polypeptide having the enzymatic activity of conversion of methylglyoxal to lactic acid in a single step (known as glyoxalase III activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the glyoxalase III activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially 1,2-propanediol, acetol, and lactic acid by fermenting microorganisms wherein their glyoxalase III activity is modulated.
Nouveau polypeptide présentant une activité enzymatique de transformation en une seule opération de méthylglyoxal en acide lactique,(dite activité de la glyoxalase III), un polynucléotide ayant une séquence nucléotidique codant pour un tel polypeptide et les utilisations correspondantes. L'invention concerne la modulation de l'activité de la glyoxalase III dans un micro-organisme par variation du niveau d'expression du polynucléotide codant pour ledit polypeptide. L'invention concerne également la production de produits du commerce, en particulier le 1,2-propanediol, l'acétol et l'acide lactique obtenus par fermentation de micro-organismes, leur activité de glyoxalase III étant modulée.
Soucaille Philippe
Voelker Francois
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Metabolic Explorer
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