Polypeptide having phospholipase a2 activity

Details Polypeptide having phospholipase a2 activity Polypeptide having phospholipase a2 activity

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/711 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61P 5/38 (2006.01) A61P 7/00 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 39/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 9/20 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2

Patent

CA 2423058

A novel phospholipase A2 polypeptide; DNA encoding this polypeptide; a vector containing this DNA; a transformant transformed by this vector; and a process for producing the above phospholipase A2 polypeptide. Methods of using the above polypeptide, for example, a method of screening a compound having an agonist or antagonist activity by using this polypeptide or an antibody thereto; and drugs containing this polypeptide or its antibody. A polypeptide (hereinafter referred to simply as the inhibitory polypeptide) inhibiting the phospholipase A2 activity of the phospholipase A2 polypeptide; DNA encoding the inhibitory polypeptide; a vector containing the DNA encoding the inhibitory polypeptide; a transformant transformed by this vector; drugs containing this inhibitory polypeptide; and a process for producing the inhibitory polypeptide.

L'invention concerne un nouveau polypeptide phospholypase A¿2?; un ADN codant ce polypeptide; un vecteur contenant cet ADN; un transformant transformé par ce vecteur; et une méthode de production dudit polypeptide phospholypase A¿2?. L'invention concerne également une méthode utilisant ce polypeptide, par exemple une méthode de criblage d'un composé ayant une activité agoniste ou antagoniste au moyen du polypeptide ou de son anticorps; et des médicaments contenant ce polypeptide ou son anticorps. Elle concerne en outre un polypeptide (ci-après dénommé simplement polypeptide inhibiteur) pouvant inhiber l'activité du polypeptide phospholypase A¿2?; un ADN codant le polypeptide inhibiteur; un vecteur contenant l'ADN codant le polypeptide inhibiteur; un transformant transformé par ce vecteur; des médicaments contenant ce polypeptide inhibiteur; et une méthode de production du polypeptide inhibiteur.

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