Polypeptide inducing apoptosis

Details Polypeptide inducing apoptosis Polypeptide inducing apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/03 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2402896

A reconstituted polypeptide characterized by inducing apoptosis in nuclear blood cells having integrin associated protein (IAP) without causing the agglutination of erythrocytes. This reconstituted polypeptide contains at least two H chain V domains and at least two L chain V domains of a monoclonal antibody which induces apoptosis in nuclear blood cells having IAP. This reconstituted polypeptide is useful as a remedy for blood diseases such as leukemia.

Cette invention a trait à un polypeptide reconstruit se caractérisant par le fait qu'il provoque une apoptose dans des cellules sanguines nucléaires possédant une protéine associée à de l'intégrine (IAP) sans entraîner l'agglutination d'érythrocytes. Ce polypeptide reconstitué possède au moins deux domaines V à chaîne lourde et au moins deux domaines à chaîne légère d'un anticorps monoclonal provoquant une apoptose dans des cellules sanguines nucléaires pourvues d'IAP. Ce polypeptide reconstruit s'avère des plus utiles comme remède contre des maladies sanguines telles que la leucémie.

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