Polypeptide monomers and dimers containing mutated ilt

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01)

Patent

CA 2670318

The present invention provides monomeric and dimeric polypeptide fusions comprising mutated human ILT molecules and immunoglobulin Fc segments. Such compostions are useful, either alone or associated with a therapeutic agent, for targeting cells expressing Class I pMHC molecules.

La présente invention concerne des fusions de polypeptides monomériques et dimériques comprenant des molécules ILT humaines mutées et des segments Fc d'immunoglobulines. Les compositions résultantes, seules ou en association avec un agent thérapeutique, sont utiles pour cibler des cellules exprimant des molécules pMHC de classe I.

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