Polypeptide-nucleic acid conjugates and uses thereof

Details Polypeptide-nucleic acid conjugates and uses thereof Polypeptide-nucleic acid conjugates and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/337 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C12N 15/00 (2006.01) C12N 15/87 (2006.01) C12N 15/18 (2006.01) C12N 15/54 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2709635

The present invention is directed to polypeptide-nucleic acid conjugates. These conjugates can allow for targeted application of a therapeutic RNAi agent across the blood-brain barrier to treat, for example, a cancer, neurodegenerative disease, or lysosomal storage disorder.

La présente invention concerne des conjugués polypeptide-acide nucléique. Ces conjugués peuvent permettre l'application ciblée d'un agent thérapeutique du type ARNi à travers la barrière hémato-encéphalique pour traiter, par exemple, un cancer, une maladie neurodégénérative, ou des troubles de stockage lysosomal.

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