Polypeptide of protein p140 and dnas encoding it

Details Polypeptide of protein p140 and dnas encoding it Polypeptide of protein p140 and dnas encoding it

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/015 (2006.01) A61K 31/045 (2006.01) A61K 31/12 (2006.01) A61K 31/13 (2006.01) A61K 31/235 (2006.01) A61K 31/425 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2136565

The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment for the currently said the prevention and/or treatment method; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylation of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).

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