Polypeptide skeletal muscle relaxants

Details Polypeptide skeletal muscle relaxants Polypeptide skeletal muscle relaxants

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/097 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2054627

Dkt. 91H918 0493S ABSTRACT POLYPEPTIDE SKELETAL MUSCLE RELAXANTS A method of achieving muscle relaxation comprising administering a polypeptide represented by the formula: Image wherein m is 0 or 1, n is 3-5, x is 0 or 2; R is lower alkyl, R1 and R2 are independently hydrogen, lower alkyl, allyl, propargyl, aryl lower alkyl, cyclo-lower alkyl lower alkyl and -COOR3 or R plus one or both of R1 and R2 and the attached nitrogen form a 5- to 7-member heterocyclic ring, at least one AA is a basic amino acid, at least one AA is a lipophilic amino acid, Y is -NH2 or -OR4, R3 is t-butyl, benzyl or fluorenylmethyl, and R4 is lower alkyl, aryl lower alkyl and N-(lower alkyl)piperidyl lower alkyl, Z is a pharmaceutically acceptable anion and, wherein m and x are 0, pharmaceutically acceptable acid addition salts thereof. Diquaternary compounds within the above formula are novel.

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