Polypeptide transition metal salts and method of enhancing...

Details Polypeptide transition metal salts and method of enhancing... Polypeptide transition metal salts and method of enhancing...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/00 (2006.01) C07K 7/08 (2006.01)

Patent

CA 2268011

Novel transition metal salts of a polypeptide represented by formula (1), having a high antiviral activity against human immunodeficiency virus (HIV). These compounds stably exhibit an anti-HIV activity higher than the one exhibited by ionic salts thereof with ordinary pharmaceutically acceptable acids because they form complex salts. A representative salt is one represented by formula (1).

L'invention concerne des nouveaux sels de métaux de transition d'un polypeptide représenté par la formule (1) et possédant une forte activité antivirale dirigée contre le virus du syndrome immunodéficitaire acquis (VIH). Ces composés possèdent de façon stable une activité dirigée contre le VIH et qui est supérieure à celle démontrée par des sels ioniques de ces composés avec des acides ordinaires et acceptables sur le plan pharmacologique, car ils formes des sels complexes. A titre d'exemple, on décrit un sel représenté par la formule (1).

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