C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/129, 530/13,
C12N 1/21 (2006.01) A61K 39/02 (2006.01) C07K 7/08 (2006.01) C07K 14/35 (2006.01) C12N 15/74 (2006.01) C12N 15/863 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1315225
ABSTRACT A Mycobacterium bovis BCG polypeptide having a molecular mass of about 64 kD was found to be useful as an immunogen inducing resistance to autoimmune arthritis and similar autoimmune diseases. The invention relates to a polypeptide comprising the epitope essential for thisactivity. The polypeptide has the formula 171 181 191 210 GVITVEESNT FGLQLELTEG MRFDKGYISG YFVTDPERQE 211 221 231 AVLEDPYILL VSSKVSTVKD LLPLLEKVIG. Further, the invention relates to polypeptides showing sequential homology with said polypeptide, and to derivatives and multimers thereof. Also, microorganismsexpressing the polypeptides either as such or as part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
546494
Cohen Irun Robert
Thole Jelle Egbertis Rudolfus
Van Der Zee Ruurd
Van Eden Willem
Van Embden Johannes Dirk Anthonie
de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W Volksgezondheid En Cultur
Mccarthy Tetrault Llp
Rijksuniversiteit Te Utrecht
Yeda Research And Development Co. Ltd.
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