Polypeptide variants with increased heparin-binding ability

Details Polypeptide variants with increased heparin-binding ability Polypeptide variants with increased heparin-binding ability

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61P 19/08 (2006.01) C07K 7/08 (2006.01) C07K 14/51 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362496

The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid sequence X1X2X3X4X5X6 (SEQ ID NO. 1 or NO.2). Polypeptide variants according to the invention are particularly suited for stimulation of chondrogenesis, osteogenesis, and wound healing. The invention also pertains to amino acid molecules that encode said polypeptide variants, host cells containing said nucleic acid molecules, and processes for producing the polypeptide variants.

L'invention concerne des variantes de polypeptides à capacité améliorée de liaison de l'héparine. Cette amélioration de la capacité de liaison de l'héparine est obtenue par addition, insertion et/ou substitution d'une séquence d'aminoacide X¿1?, X¿2?, X¿3?, X¿4?, X¿6? (SEQ ID n·1 ou n·2). Les variantes de polypeptides selon l'invention s'utilisent notamment pour stimuler la chondrogenèse, l'ostéogenèse et la cicatrisation. L'invention concerne en outre des molécules d'acide nucléique codant ces variantes de polypeptide, des cellules-hôtes comprenant ces molécules d'acide nucléique et des procédés permettant de préparer ces variantes de polypeptides.

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