Polypeptide with reduced allergenicity

Details Polypeptide with reduced allergenicity Polypeptide with reduced allergenicity

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A23K 1/165 (2006.01) A61K 8/64 (2006.01) A61K 8/66 (2006.01) A61K 8/72 (2006.01) A61K 8/86 (2006.01) A61K 38/48 (2006.01) A61Q 5/00 (2006.01) A61Q 11/00 (2006.01) A61Q 19/00 (2006.01) C07K 17/02 (2006.01) C11D 3/00 (2006.01) C11D 3/386 (2006.01) C12N 11/02 (2006.01) C12N 11/08 (2006.01) C12N 11/10 (2006.01) C12S 9/00 (2006.01) H01S 5/14 (2006.01)

Patent

CA 2206852

The invention relates to modified polypeptides with reduced allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (Mr) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and further ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.

L'invention concerne des peptides modifiés à allergénicité réduite, comprenant un polypeptide parent présentant une masse molaire comprise entre 10 kDa et 100 kDa et conjugué à un polymère dont la masse molaire (M¿r?) est de l'ordre de 1 kDa à 60 kDa. On produit lesdits polypeptides modifiés selon l'invention par un procédé qui consiste à conjuguer 1 à 30 molécules polymères audit polypeptide parent. L'invention se rapporte également à des compositions comprenant lesdits polypeptides et d'autres ingrédients normalement utilisés, par exemple, dans les détergents, dont les détergents vaisselle, les pains de savon, les articles ménagers, les produits agrochimiques, les produits d'hygiène personnelle, les produits cosmétiques, de toilette, les produits pharmaceutiques buvables et dermiques, les préparations pour le traitement des textiles, et les compositions utilisées pour la fabrication de produits alimentaires et d'aliments pour animaux. Pour conclure, l'invention porte sur les utilisations desdits polypeptides à allergénicité réduite ou des compositions de ces derniers dans un grand nombre d'applications industrielles.

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