Polypeptides and biosynthetic pathways for the production of...

Details Polypeptides and biosynthetic pathways for the production of... Polypeptides and biosynthetic pathways for the production of...

C - Chemistry, Metallurgy

12

N

C12N 15/61 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 9/90 (2006.01) C12P 13/04 (2006.01) C12P 13/22 (2006.01) C12N 9/06 (2006.01) C12N 9/88 (2006.01) C12N 15/63 (2006.01) C12P 17/10 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2666348

Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

Selon la présente invention, la monatine et certains stéréoisomères de monatine, telles la monatine R,R et la monatine R,S, ainsi que leurs sels, sont obtenus à l'aide de polypeptides et de voies de synthèse biologique. Ces polypeptides et voies de synthèse biologique sont utiles lors de la production d'acide glutarique de R-2-hydroxy-2-(indoly-3-ylméthyl)-4-céto, un intermédiaire formé dans certaines voies de synthèse de la monatine, notamment certaines voies de synthèse biologique.

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