Polypeptides and biosynthetic pathways for the production of...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/90 (2006.01) C12N 9/10 (2006.01) C12P 13/04 (2006.01) C12P 17/10 (2006.01) C12N 1/21 (2006.01) C12P 13/22 (2006.01)

Patent

CA 2638896

Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

L'invention concerne de la monatine et certains stéréoisomères de monatine, tels que la monatine R,R et S,R, ainsi que des sels de ceux-ci, produits à partir de polypeptides et de voies de synthèse biologique. Ces polypeptides et ces voies de synthèse biologique sont utiles dans la production d'un acide glutarique de R-2-hydroxy-2-(indoly-3-ylméthyl)-4-céto, un intermédiaire formé dans certaines voies de synthèse de la monatine, notamment certaines voies de synthèse biologique.

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