C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/135, 167/37,
C12N 1/21 (2006.01) A61K 39/04 (2006.01) C07K 7/06 (2006.01) C07K 14/35 (2006.01) G01N 33/564 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1325612
ABSTRACT A polypeptide having amino acid sequence 172-192 of a Mycobacterium bovis BCG 64 kD polypeptide, said sequence having the formula Image as well as polypeptides derived therefrom, in the amino acid sequence of which sequence 172-179 and/or sequence 189-192 is (are) entirely or partially absent, were found to be useful as immunogens inducing resistance to auto-immune arthritis and similar auto-immune diseases. The invention relates to these polypeptides, to polypeptides showing sequential homology with these polypeptides, and to derivatives and multimers thereof. Also, microorganisms expressing the polypeptides either as such or as part of a fusion protein or as a multimer form part of the invention. Finally, the invention relates to pharmaceutical compositions, diagnostic compositions and test kits comprising a compound according to the invention.
586746
Cohen Irun R.
Van Der Zee Ruurd
Van Eden Willem
Van Embden Johannes D. A.
Cohen Irun R.
de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W Volksgezondheid En Cultuur
Mccarthy Tetrault Llp
Rijksuniversiteit Te Utrecht
Van Der Zee Ruurd
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