Polypeptides and dna coding therefor

Details Polypeptides and dna coding therefor Polypeptides and dna coding therefor

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07K 14/81 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070399

2070399 9109947 PCTABS00006 A serine protease inhibitor, similar in some respects to .alpha.1-antitrypsin (AAT) but having an unglycosylated molecular weight on PAGE of 32±1 kDa, has been discovered. cDNA encoding the active protein has been cloned and sequenced, so the sequence of the protein has been revealed. Recombinant DNA technology enables the natural polypeptide sequence and related proteins to be prepared, for example by expression in E. coli. The inhibitor may prove useful in the treatment of emphysema, arthritis or septic shock.

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