C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/00 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07K 7/06 (2006.01) C07K 14/315 (2006.01) C07K 14/37 (2006.01) C07K 16/12 (2006.01) C07K 16/14 (2006.01) C12N 1/13 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) G01N 33/53 (2006.01) G01N 33/569
Patent
CA 2552188
A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full- length Pneumocystis kexin, or a full length Streptococcus pneumoniae pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by aPneumocystis organism, in a patient.
L'invention concerne un certain nombre d'agents immunologiquement actifs, notamment une protéine isolée ou un polypeptide qui comprend la séquence d'acides aminés de SEQ ID NO: 1, des conjugués immunogènes contenant la protéine ou le polypeptide, une kexine de Pneumocystis pleine longueur, ou une protéine A de surface pneumococcique de Streptococcus pneumoniae pleine longueur (PspA), des anticorps reconnaissant la protéine ou le polypeptide ou les conjugués immunogènes (en particulier l'épitope de SEQ ID NO: 1), et des molécules d'acide nucléique qui codent pour la protéine ou le polypeptide, ainsi que des constructions d'ADN, des vecteurs d'expression et des cellules hôtes qui contiennent les molécules d'acide nucléique. L'invention concerne des utilisations desdits anticorps, conjugués immunogènes et constructions d'ADN consistant à induire une immunité active ou passive afin de traiter ou de prévenir des infections pathogènes, notamment par un organisme de Pneumocystis, chez un patient.
Gigliotti Francis
Haidaris Constantine G.
Simpson-Haidaris Patricia J.
Wells Jesse
Wright Terry W.
Gowling Lafleur Henderson Llp
University Of Rochester
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