C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2745492
This invention relates to a novel target for production of immune and non- immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
La présente invention concerne une nouvelle cible pour la production d'agents thérapeutiques à base immunitaire et non immunitaire et pour des diagnostics de maladie. Plus particulièrement, l'invention concerne des anticorps thérapeutiques contre les antigènes KRTCAP3, FAM26F, MGC52498, FAM70A ou TMEM154, qui sont exprimés de manière différentielle dans le cancer, et des utilisations diagnostiques et thérapeutiques. Cette invention concerne en outre des domaines extracellulaires des protéines KRTCAP3, FAM26F, MGC52498, FAM70A et TMEM154 et des variants, et des utilisations thérapeutiques de ceux-ci.
Beiman Merav
Cohen-Dayag Anat
Dassa Liat
Kinar Yaron
Levine Zurit
Borden Ladner Gervais Llp
Compugen Ltd.
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