Polypeptides and polynucleotides, and uses thereof as a drug...

Details Polypeptides and polynucleotides, and uses thereof as a drug... Polypeptides and polynucleotides, and uses thereof as a drug...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C12N 15/113 (2010.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2698369

This invention relates to a novel target for production of immune and non- immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants awhich are suitable targets for immunotherapy, cancer therapy, and drug development.

Cette invention concerne une nouvelle cible pour la production de substances thérapeutiques à base de produits immuns et non immuns, et pour le diagnostic de maladies. Plus particulièrement, l'invention concerne des anticorps thérapeutiques contre les antigènes VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 ou FXYD3 dont on prédit qu'ils sont membres de familles co-stimulatrices et qui sont différentiellement exprimés dans des cancers, notamment cancer du poumon, cancer de l'ovaire, et cancer du côlon, et des utilisations diagnostiques et thérapeutiques. L'invention concerne également l'utilisation de ces anticorps pour moduler la costimulation de B7 et pour des thérapies apparentées, comme le traitement de l'auto-immunité. Cette invention concerne en outre la découverte de domaines extracellulaires de VSIG1 et de ses variants, de FXYD3 et de ses variants, d'ILDR1 et de ses variants, de LOC253012 et de ses variants, d'AI216611 et de ses variants, et de C1ORF32 et de ses variants qui constituent des cibles appropriées à l'immunothérapie, à la thérapie du cancer, et au développement de médicaments.

Affiliated with

Also associated with

Rating

Polypeptides and polynucleotides, and uses thereof as a drug... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides and polynucleotides, and uses thereof as a drug..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides and polynucleotides, and uses thereof as a drug... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1809867