Polypeptides and polynucleotides, and uses thereof as a drug...

Details Polypeptides and polynucleotides, and uses thereof as a drug... Polypeptides and polynucleotides, and uses thereof as a drug...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2713667

This invention relates to a novel target for production of immune and non- immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.

La présente invention concerne une nouvelle cible pour produire des médicaments immunothérapeutiques et non immunothérapeutiques et destinés au diagnostic des pathologies. Linvention concerne plus particulièrement des anticorps thérapeutiques dirigés contre les antigènes KIAA0746, CD20 ou CD55 qui sont exprimés de manière différentielle dans les cellules cancéreuses et dans les cellules sanguines spécifiques et elle concerne aussi les utilisations à titre diagnostique et thérapeutique. La présente invention concerne en outre la découverte de domaines extracellulaires du KIAA0746 et de ses variants, du CD20 et de ses variants ainsi que du CD55 et de ses variants qui forment des cibles adaptées à l'immunothérapie, à l'oncothérapie, au traitement des troubles inflammatoires, allergiques et d'origine auto-immune ainsi qu'au développement de médicaments.

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