Polypeptides and polypeptide analogues with inhibitory...

C - Chemistry – Metallurgy – 12 – N

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167/103.05, 530/

C12N 15/15 (2006.01) A61K 38/02 (2006.01) A61K 38/55 (2006.01) C07H 21/00 (2006.01) C07K 2/00 (2006.01) C07K 14/39 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2018592

Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro- Ile-Ile-Leu-Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys- Asp-Thr-Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met- Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.

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