C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2688447
The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
L'invention concerne des polypeptides anti-TNFR1 et des domaines variables simples d'anticorps (dAbs) résistant à la dégradation causée par une protéase, ainsi que des antagonistes comprenant ceux-ci. Les polypeptides, les dAbs et les antagonistes sont utilisés comme agents thérapeutiques et/ou prophylactiques susceptibles de trouver des protéases lorsqu'ils ont administrés à un patient, par exemple dans le cas d'une administration pulmonaire, d'une administration orale, d'une administration dans les poumons et d'une administration dans le tractus gastro-intestinal d'un patient, ainsi que dans le traitement d'une maladie inflammatoire, telle que l'arthrite ou la BPCO.
Enever Carolyn
Jespers Laurent
Pupecka Malgorzata
Tomlinson Ian
Domantis Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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