C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/129, 530/13,
C12N 15/30 (2006.01) A61K 39/018 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C07K 19/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2008622
ABSTRACT An antigen which produces immunity against homologous or heterologous challenge with babesia of cattle. The antigen is immunoreactive with a monoclonal antibody or polyclonal antisera recognising a protein located on the surface of babesia-infected erythrocytes and within a spherical or mitochondrion like organelle. The antigen can be prepared by (i) preparing nucleic acids from babesia injected erythrocytes depleted of leucocytes; (ii) forming a cDNA or genomic library from nucleic acids obtained in step (i); (iii) screening said library formed in step (ii) with a suitable probe to identify clones of interest; and thus providing DNA inserts for an expression vector which may be used to transform an appropriate host; (iv) obtaining a recombinant polypeptide from said transformed hosts which is protective against babesiosis. A monoclonal antibody reactive with the antigen, a DNA sequence which produces a protein protective against babesiosis when administered as a vaccine, and a vaccine including the antigen in combination with an adjuvant is also included in the inventive concept.
Gale Kevin R.
Goodger Brian V.
Waltisbuhl David J.
Wright Ian G.
Commonwealth Scientific And Industrial Research Organisation
Mccarthy Tetrault Llp
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