Polypeptides capable of binding to cd64 and comprising one...

Details Polypeptides capable of binding to cd64 and comprising one... Polypeptides capable of binding to cd64 and comprising one...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2435672

The invention relates to the use of a polypeptide which comprises i) a first portion comprising the part of human Fc which binds to CD64, and ii) a second portion comprising one or more heterologous T cell epitopes for stimulating a cytotoxic T cell response. The polypeptide may be an antibody which may be used to stimulate an cytotoxic T cell response against pathogens and tumour cells in patients in need of such treatment.

L'invention concerne l'utilisation d'un polypeptide qui comporte i) une première portion comprenant l'élément humain Fc qui se lie au CD64, et ii) une seconde portion comprenant au moins un épitope de cellule T hétérologue destiné à stimuler une réponse de cellule T cytotoxique. Le polypeptide peut être un anticorps pouvant servir à stimuler une réponse de cellule T cytotoxique contre des pathogènes et cellules tumorales chez des patients nécessitant un tel traitement.

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