Polypeptides coded by exon v5 of the cd44 gene as targets...

Details Polypeptides coded by exon v5 of the cd44 gene as targets... Polypeptides coded by exon v5 of the cd44 gene as targets...

C - Chemistry, Metallurgy

07

K

C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2168988

The present invention relates to agents for the treatment and in vivo diagnosis of tumours based on the selective bonding of antibodies to epitopes coded by variant exons of the CD44 gene. Special preference is hereby given to exon v5 of the human CD44 gene. Exon v5 is expressed in normal tissues only very slightly or not at all, whereas even at early stages of tumour progression it is expressed in large quantities. Therefore v5-coded epitopes are very suitable as targets for the immunotherapy and immunoscintigraphy of tumours.

La présente invention concerne des agents appropriés à la thérapie et au diagnostic in vivo de tumeurs qui reposent sur la fixation sélective d'anticorps à des épitopes codés par des exons variants du gène CD44. A cet effet, on donne la préférence à l'exon v5 du gène humain CD44. L'exon v5 n'est pas ou n'est que très faiblement exprimé dans des tissus normaux, tandis qu'il est fortement exprimé dans un très grand nombre de tumeurs, même à un stade précoce. C'est pourquoi les épitopes codés par v5 conviennent très bien comme cibles pour l'immunothérapie et l'immunoscintigraphie des tumeurs.

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