Polypeptides comprising fas activation and nkg2d-ligand domains

Details Polypeptides comprising fas activation and nkg2d-ligand domains Polypeptides comprising fas activation and nkg2d-ligand domains

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2670790

The present invention is drawn to fusion proteins comprising (a) a ligand for an NK receptor and (b) an intracytoplasmic death domain, and to nucleic acids encoding such fusion proteins. The invention also includes methods of making and using such proteins and nucleic acids, including their use in preventing or treating cancer.

L'invention se rapporte à des protéines de fusion comprenant (a) un ligand de récepteur NK et (b) un domaine d'activation Fas, et à des acides nucléiques codant lesdites protéines de fusion. L'invention concerne également des procédés de fabrication et d'utilisation des protéines et acides nucléiques précités, y compris dans la prévention ou le traitement du cancer.

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