C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 31/711 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/00 (2006.01) C07K 14/515 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2268045
The invention concerns polynucleotides comprising GAX domains, involved in the biological activity of GAX. In particular it may concern domains involved in the interaction of GAX with other molecules or domains responsible for a biological activity. The invention also concerns the chimerical molecules comprising a functional domain of GAX. It further concerns the use of GAX for repressing the expression of genes, and the use of compounds inhibiting the interaction of GAX with certain cell partners for modulating the activity of GAX, It also concerns a method for screening and/or identifying cell partners of GAX.
La présente invention concerne des polynucléotides comprenant des domaines de GAX impliqués dans l'activité biologique de GAX. Il peut s'agir notamment de domaines impliqués dans l'interaction de GAX avec d'autres molécules ou de domaines responsable d'une activité biologique. L'invention concerne également des molécules chimeriques comprenant un domaine fonctionnel de GAX. Elle concerne également l'utilisation de GAX pour réprimer l'expression de gènes, ainsi que l'utilisation de composés inhibant l'interaction de GAX avec certains partenaires cellulaires pour moduler l'activité de GAX. Elle concerne également une méthode pour le criblage et/ou l'identification de partenaires cellulaires de GAX.
Branellec Didier
Fournier Alain
Mahfoudi Abderrahim
Marcireau Christophe
Rhone-Poulenc Rorer S.a.
Robic
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