Polypeptides, dna coding therefor, formulations thereof, and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/58 (2006.01) A61K 48/00 (2006.01) A61P 7/00 (2006.01) C07K 14/81 (2006.01) C07K 14/815 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2318358

A polypeptide, derivable from a Haementeria leech, which polypeptide is suitable for inhibiting C1 esterase and/or factor XII activation is disclosed, together with a nucleic acid sequence encoding the polypeptide. The polypeptide may be used as a pharmaceutical formulation or in gene therapy to treat or prevent cardiovascular, inflammatory or auto-immune disorders.

L'invention porte sur un polypeptide pouvant être dérivé d'une sangsue Haementeria et qui est approprié pour inhiber l'activation d'estérase C1 et/ou du facteur XII, une séquence d'acide nucléique codant le polypeptide. Ce polypeptide peut être utilisé dans une formulation pharmaceutique ou en thérapie génique pour traiter ou prévenir les maladies cardio-vasculaires, inflammatoires ou autoimmunes.

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