A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/085 (2006.01)
Patent
CA 2593265
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC- AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full lengthS. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus.
La présente convention porte sur des polypeptides comprenant une séquence d'acides aminés apparentée structurellement à SEQ ID NO: 1 ou à un fragment de celle-ci, sur des compositions S. aureus AhpC-AhpF et sur les utilisations de ces polypeptides et de ces compositions. SEQ ID NO: 1 a une séquence S. aureus AhpC pleine longueur. Il s'avère qu'un dérivé de SEQ ID NO: 1 contenant His-tag amino et trois aminoacides carboxyliques additionnels peut produire une réponse immune protectrice contre S. aureus.
Kelly Rosemarie
Mcneely Tessie
Miller Mark A.
Schultz Loren D.
Yeager Mark D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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