C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C12N 15/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2579225
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. aureus polypeptide. The full- length polypeptide is referred to herein as full-length penicillin-binding protein 4 (~PBP4~). A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
L'invention porte sur des polypeptides comprenant une séquence d'acides aminés structurellement apparentée à la SEQ ID NO: 1 et sur l'utilisation desdits polypeptides. La SEQ ID NO: 1 est un dérivé tronqué du polypeptide pleine longueur du <i>S. aureus</i>, ledit polypeptide pleine longueur étant ici dit dans la description "protéine 4 (PBP4) pleine longueur de fixation de la pénicilline". On a découvert que le dérivé à marquage His de la SEQ ID NO: 1 produisait un réponse immunitaire protectrice contre le <i>S. aureus</i>.
Anderson Annaliesa S.
Montgomery Donna L.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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