C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/31 (2006.01) A61K 38/00 (2006.01) A61K 39/085 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2675992
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.
La présente invention concerne des polypeptides comprenant une séquence d'acides aminés structuralement apparentée à SEQ ID NO:1 et des utilisations de tels polypeptides. SEQ ID NO:1 est un dérivé tronqué d'un polypeptide de S. epidermidis de longueur entière. Le polypeptide apparaissant dans la nature de longueur entière est appelé ici ORF1319e de longueur entière. Un dérivé marqué par His de SEQ ID NO:1 a été trouvé produire une réponse immunitaire protectrice contre S. epidermidis.
Anderson Annaliesa S.
Cook James C. III
Mcclements William L.
Mcneely Tessie
Montgomery Donna L.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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