C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) A61K 39/09 (2006.01) C07K 2/00 (2006.01)
Patent
CA 2555342
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full- length polypeptide is referred to herein as full-length ~sai-1~. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
Des polypeptides comprenant une séquence d'acides aminés en rapport structurel avec SEQ ID NO: 1 et leurs utilisations. La SEQ ID NO: 1 est un dérivé tronqué d'un polypeptide S. aureus à longueur plein. Ce polypeptide apparaît comme sai-1 . Un dérivé à marque His de SEQ ID NO: 1 permet de produire une réponse immune protectrice contre S. aureus.
Anderson Annaliesa S.
Montgomery Donna L.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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