A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) C07K 1/00 (2006.01)
Patent
CA 2565330
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a derivative of a full lengthS. aureus polypeptide. The full-length naturally occurring polypeptide is referred to herein as full length ~ORF0826~. The SEQ ID NO: 1 derivative contains an alanine addition after the initial methionine. A His-tag derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. aureus.
La présente invention se rapporte à des polypeptides comportant une séquence d'acides aminés structurellement associée à SEQ ID NO: 1 et aux utilisations de ces polypeptides. SEQ ID NO: 1 est un dérivé d'un polypeptide de <i>S. aureus</i> pleine longueur. Ce polypeptide pleine longueur naturel est référencé ici comme "ORF0826" pleine longueur. Le dérivé SEQ ID NO: 1 contient un ajout d'alanine après la méthionine initiale. Un dérivé His-tag de SEQ ID NO: 1 s'est avéré produire une réponse immunitaire de protection contre <i>S. aureus</i>.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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