Polypeptides for modulating binding of trp channel proteins...

Details Polypeptides for modulating binding of trp channel proteins... Polypeptides for modulating binding of trp channel proteins...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 31/7105 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07K 7/00 (2006.01) C07K 14/155 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2551190

This invention relates to inhibitors and modulators of the binding between a transcient receptor potential (TRP) channel protein and a TRP-associated binding protein. In particular inhibitors and modulators of the binding between the TRPM7 channel protein and PDZ-domain containing TRP-associated proteins. These modulators and inhibitors are used to control Ca2+ transport through TRPM7 channel proteins and reduce damage to mammalian cells, including brain and spinal cord cells, after ischemia or traumatic injury.

La présente invention a trait à des inhibiteurs et des modulateurs de la liaison entre une protéine du canal de récepteur de potentiel transitoire (TRP) et une protéine de liaison associée au canal de récepteur de potentiel transitoire, notamment des inhibiteurs et des modulateurs de la liaison entre la protéine du canal TRPM7 et les protéines associées au récepteur de potentiel transitoire contenant le domaine PDZ. Ces modulateurs et inhibiteurs sont utilisés pour le contrôle du transport de Ca2+ à travers les protéines du canal TRPM7 et réduisent la détérioration des cellules mammaliennes, comprenant les cellules cérébrales et de la moelle épinière, suite à une ischémie ou une lésion traumatique.

Affiliated with

Also associated with

Rating

Polypeptides for modulating binding of trp channel proteins... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polypeptides for modulating binding of trp channel proteins..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polypeptides for modulating binding of trp channel proteins... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1810127