Polypeptides for oligomeric assembly of antigens

Details Polypeptides for oligomeric assembly of antigens Polypeptides for oligomeric assembly of antigens

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01)

Patent

CA 2574375

A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antigenic polypeptide into close proximity in the form of an oligomer. Expressing the polypeptides in oligomeric form in this way can improve their immunogenicity compared to a monomeric form.

L'invention concerne un système permettant d'exprimer des polypeptides antigéniques sous forme oligomère, qui induit la fusion du polypeptide antigénique en un polypeptide de polymérisation, de sorte que le polypeptide de polymérisation puisse entrer en interaction avec d'autres polypeptides de polymérisation et amener de multiples copies du polypeptide antigénique en proximité mutuelle immédiate, sous la forme d'un oligomère. Le fait d'exprimer ainsi les polypeptides sous forme oligomère permet d'améliorer leur immunogénécité, comparativement à une forme monomère.

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