C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01)
Patent
CA 2750005
The invention relates to polypeptides which enable the specific targeting of a molecule of interest to homeoprotein Otx2 target cells. These polypeptides are defined by the general sequence: B1B2X1B3B4X2B5X3X4X5X6B6X7X8X9 (SEQ ID NO: 1), in which: B1, B2, B3, B4, B5 and B6 are independently arginine or lysine; X1 and X8 are independently asparagine or glutamine; X2 is aspartic acid or glutamic acid; X3, X4 and X6 are independently threonine or serine; X5 is phenylalanine, tyrosine or tryptophan; X7 represents alanine or glycine; X9 is leucine, isoleucine or valine.
L'invention est relative à des polypeptides permettant l'adressage spécifique d'une molécule d'intérêt à des cellules--cibles de Phoméoprotéine Otx2. Ces polypeptides sont définis par la séquence générale : B1B2X1B3B4X2B5X3X4X5X6B6X7X8X9 (SEQ ID NO: 1), dans laquelle : B1, B2, B3, B4, B5 et B6 représentent indépendamment l'arginine ou la lysine; X1 et X8 représentent indépendamment l'asparagine ou la glutamine; X2 représente l'acide aspartique ou l'acide glutamique; X3, X4 et X6 représentent indépendamment la thréonine ou la serine; X5 représente la phénylalanine, la tyrosine ou le tryptophane; X7 représente l'alanine ou la glycine; X9 représente la leucine, l'isoleucine ou la valine.
Beurdeley Marine
Di Nardo Ariel
Prochiantz Alain
Centre National de La Recherche Scientifique
Ecole Normale Superieure
Robic
LandOfFree
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