Polypeptides having a single covalently bound n-terminal...

Details Polypeptides having a single covalently bound n-terminal... Polypeptides having a single covalently bound n-terminal...

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/505 (2006.01)

Patent

CA 2262994

This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal .alpha.- carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.

La présente invention décrit des compositions comportant essentiellement un polypeptide et un polymère soluble dans l'eau qui lui est lié par covalence à l'atome de carbone .alpha. N-terminal via un hydrazone ou une liaison hydrazone réduite, ou une oxime ou une liaison oxime réduite. L'invention décrit aussi des procédés d'élaboration de compositions instantanées, de compositions pharmaceutiques comportant lesdites compositions et les kits d'utilisation desdites compositions.

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